Importance of the Pharmacological Synergism in Modern Concept of Anti-Ischemic Therapy


Importance of the Pharmacological Synergism in Modern Concept of Anti-Ischemic Therapy

Research & Reviews: Journal of Hospital and Clinical Pharmacy (RROIJ Publishing) is an open access, peer-reviewed journal that focuses and welcomes submissions on all aspects of  not only Hospital and Clinical pharmacy but also in aspects like Drugs & Drug information studies, General anesthesia, Automatized anesthesia, Pediatric Anesthesia, Obstetric Anesthesia, Neuroanesthesia, All kind of surgeries General medicine & Critical care medicine, Preoperative Evaluation & Postoperative effects, Pain management, Drug information studies, Clinical reviews, Pharmacy practices, Patient care & Counseling, Ischemia reperfusion, Clinical trials, Patient management, Patient care, Nursing, Disease and hospitalization, Trauma care, and Incentive care etc.  

It gives us great pleasure to announce the call for paper on the occasion of 10th Anniversary of the Journal at special and hefty discount of up to 50 % on one-time article processing charge. Prospective academicians and scientists are encouraged to utilize this opportunity to get their articles reviewed, processed and published at relatively faster pace and at lower charges. In addition to this, the authors who publish with us during the year-long celebrations will also be eligible for academic awards recommended by the editorial panel.

The Archive page contains wide variety of articles such as Research / Review / Case reports / short communication / Mini review / Prospective / Letter to Editors Etc. We would like introduce a Research article which has been spread to the widest audience of experts; and thus increased in readership, citations and altimetry score.

Title: “Importance of the Pharmacological Synergism in Modern Concept of Anti-Ischemic Therapy”

Abstract: Nowadays, the increase of therapy efficacy of ischemic conditions in cardiology and neurology is one of the top trends in clinical, pharmaceutical and pharmacological studies on a global scale. In this article the issues of anti-ischemic therapy optimization by the example of the combined use of precursors and carnitine analogues – trimethylhydrasine propionate (TMHP) and γ-butyrobetaine (GBB) are reviewed. The pharmacodynamics advantages of this combined use are characterized by the occurrence of the synergistic phenomenon in the form of a mutual potentiation of its effects. TMHP is a famous cardio- and neuroprotector; in the binary mechanism of its action the metabolic component is more significant than vasodilatation one and its combination with GBB makes up for this shortcoming. Adding GBB, on the background of inhibiting its conversion into carnitine under the impact of TMHP, leads to its quick accumulation in the ischemic tissues, to reinforcement of nitrogen oxide synthesis and to vasodilatation high-speed development of, which, in turn, substantially enhances the pharmacodynamic metabolic component of the given combination. The present concept has underlaid the development of the original regulator of the vascular endothelial function − the drug "Capicor", which has unified the advantages of metabolic and endothelial cytoprotector TMHP, as well as endothelial corrector of GBB.

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Research & Reviews: Journal of Hospital and Clinical Pharmacy