Molecular Mechanism of Attenuated Inverse Agonism of ARBs for Active-State of AT1 receptor


Molecular Mechanism of Attenuated Inverse Agonism of ARBs for Active-State of AT1 receptor

Research & Reviews: Journal of Hospital and Clinical Pharmacy (RROIJ Publishing) is an open access, peer-reviewed journal that focuses and welcomes submissions on all aspects of  not only Hospital and Clinical pharmacy but also in aspects like Drugs & Drug information studies, General anaesthesia, Automatized anaesthesia, Paediatric Anaesthesia, Obstetric Anaesthesia, Neuroanesthesia, All kind of surgeries General medicine & Critical care medicine, Preoperative Evaluation & Postoperative effects, Pain management, Drug information studies, Clinical reviews, Pharmacy practices, Patient care & Counselling, Ischemia reperfusion, Clinical trials, Patient management, Patient care, Nursing, Disease and hospitalization, Trauma care, and Incentive care etc.  

It gives us great pleasure to announce the call for paper on the occasion of 10th Anniversary of the Journal at special and hefty discount of up to 50 % on one-time article processing charge. Prospective academicians and scientists are encouraged to utilize this opportunity to get their articles reviewed, processed and published at relatively faster pace and at lower charges. In addition to this, the authors who publish with us during the year-long celebrations will also be eligible for academic awards recommended by the editorial panel.

The Archive page contains wide variety of articles such as Research / Review / Case reports / short communication / Mini review / Prospective / Letter to Editors Etc. We would like introduce a Review article which has been spread to the widest audience of experts; and thus increased in readership, citations and altimetry score.

Title: “Molecular Mechanism of Attenuated Inverse Agonism of ARBs for Active-State of AT1 receptor

Abstract: Typically AngII the octapeptide hormone produced by the renin angiotensin system binds to angiotensin II type 1 receptor (AT1R) and activates its functions which can be competitively inhibited by AT1R blockers (ARBs). However several studies have demonstrated ligand independently activated AT1R in clinical setting such as mechanical stretch and auto-antibodies as well as receptor mutations. Clinically used ARBs prevent ligand-independent activation of the AT1R by inverse agonistic effect with variable efficacies. Ligand-independent transition of AT1R to activated state is known to attenuate inverse agonistic efficacy of the ARBs but the molecular mechanism is unknown. Therefore, identifying the molecular basis of reduced inverse agonist efficacy of ARBs for the active-state of the AT1R provided a fundamental insight for application of ARBs in treatment of diseases as well as for future drug development. Since AT1R is an extensively studied member of G-protein coupled receptor superfamily encoded in human genome the new regulatory mechanisms of inverse agonist function we describe is relevant to disorders caused by other members of this superfamily. In this review, we focus on the molecular mechanism of attenuated inverse agonism of the ARBs.

To have a glance at the full length manuscript, you can visit us at our archive page and Currently, Journal’s Archive is holding not only normal issues but also focusing on special issues. The purpose of special issues is to publish the most exciting research with respect to the subjects of Hospital and Clinical Pharmacy and to provide a rapid turn-around time regarding reviewing and publishing, and to publicize the articles freely for research, teaching and reference purposes. Submit manuscript of your research articles or special issue articles online through manuscript submission or forwarded to the Editorial Office at

Point of Contact

John Robert

Editorial Assistant

Research & Reviews: Journal of Hospital and Clinical Pharmacy